I love the layout.
I love Spideys' body language and anatomy. The only thing that I'm not really liking is Mary Jane. For starters her hand bothers me. Something about it reads a little too clawlike. Her hand in my humble opinion is too....defined. Especially in the wrist area.
I also think that her thumb is too meaty. Too much like the hand of somone who lifts weights regularly....or who has had the privelege of punching super villians in the face! The only thing that I'm not liking is the position/shape of her eye. It does look a bit too asian to be Mary Jane. Other than that, good job as usual!